5 AMINO 1 MQ
PopularSelective NNMT inhibitor studied for metabolic support and NAD+ preservation
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• Major cities (JHB, CPT, DBN): R195 overnight
• Outlying areas: R275 (2-3 business days)
• Collect in person: Free (Sandton location)
5-Amino-1-methylquinolinium (5-Amino-1MQ) is a selective, membrane-permeable small molecule inhibitor of nicotinamide N-methyltransferase (NNMT). This compound has gained research attention for its role in cellular metabolism, NAD+ preservation, and energy production. By targeting NNMT activity, 5-Amino-1MQ influences metabolic pathways that affect fat storage, energy utilization, and cellular longevity mechanisms.
- •Inhibition of NNMT enzyme activity to support metabolic function
- •Preservation and enhancement of intracellular NAD+ levels
- •Support for efficient cellular energy production
- •Reduction in lipogenesis (fat formation) in adipocytes
- •Activation of SIRT-1 gene pathways associated with longevity
- •Enhanced mitochondrial function and metabolic rate
- •Support for DNA repair mechanisms through NAD+ availability
5-Amino-1MQ works by selectively binding to the nicotinamide-binding site of NNMT, effectively blocking its enzymatic activity. NNMT normally converts nicotinamide (a form of vitamin B3) into N-methylnicotinamide, which depletes cellular NAD+ pools. By inhibiting NNMT, 5-Amino-1MQ preserves NAD+ levels, which are crucial for mitochondrial function, DNA repair, and activation of sirtuins (longevity proteins). This inhibition also reduces fat cell size, decreases inflammation in adipose tissue, and enhances overall metabolic efficiency.
* Metabolic syndrome and obesity research * NAD+ metabolism and cellular energy studies * Mitochondrial function investigations * Adipocyte biology and lipogenesis research * Longevity and anti-aging pathway studies * SIRT-1 activation and sirtuin biology research * Cellular energy homeostasis investigations
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Research Use Only
This product is sold strictly for research purposes only. It is not approved by the FDA for human consumption or medical use. Intended for laboratory and research applications by qualified researchers and institutions only.