GHRP-2
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• Major cities (JHB, CPT, DBN): R195 overnight
• Outlying areas: R275 (2-3 business days)
• Collect in person: Free (Sandton location)
GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide and second-generation growth hormone secretagogue that acts as a ghrelin receptor agonist. It stimulates the pituitary gland to release growth hormone (GH) in a pulsatile manner, mimicking the body's natural GH secretion patterns. GHRP-2 is widely used in research settings to study growth hormone physiology, metabolic regulation, and aging processes.
- •Potent stimulation of growth hormone release from the pituitary gland
- •Moderate ghrelin receptor activation with appetite-stimulating effects
- •Synergistic effects when combined with GHRH analogs (e.g., CJC-1295)
- •Dose-dependent GH release with predictable response curves
- •Supports research into metabolic regulation and body composition
GHRP-2 binds to and activates the growth hormone secretagogue receptor (GHS-R1a), also known as the ghrelin receptor, located on somatotroph cells in the anterior pituitary gland. This activation triggers a cascade of intracellular signaling events involving phospholipase C (PLC), inositol triphosphate (IP3), and diacylglycerol (DAG), leading to increased intracellular calcium levels. The elevated calcium concentration stimulates the exocytosis of growth hormone-containing vesicles, resulting in GH release into the bloodstream. Additionally, GHRP-2 activates ghrelin pathways in the hypothalamus, which can suppress somatostatin release (a GH inhibitor) and enhance the effects of growth hormone-releasing hormone (GHRH). This dual mechanism makes GHRP-2 particularly effective when used in combination with GHRH analogs, producing synergistic GH release that exceeds the sum of their individual effects.
GHRP-2 is valuable in research investigating growth hormone physiology, including studies on pulsatile GH secretion patterns, GH reserve testing, and the regulation of the somatotropic axis. It is used in metabolic research to examine the effects of GH on body composition, fat metabolism, and muscle protein synthesis. GHRP-2 is also employed in aging research to study age-related declines in GH secretion and their metabolic consequences. Comparative studies with other growth hormone secretagogues (GHRP-6, Ipamorelin, Hexarelin) help elucidate the specific characteristics and optimal applications of different GHS-R agonists.
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CJC-1295 with DAC
Long-acting growth hormone-releasing hormone analog with extended half-life
CJC-1295 without DAC
Shorter-acting GHRH analog providing pulsatile growth hormone release
Ipamorelin
Selective growth hormone secretagogue with minimal side effects
GHRP-6
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Research Use Only
This product is sold strictly for research purposes only. It is not approved by the FDA for human consumption or medical use. Intended for laboratory and research applications by qualified researchers and institutions only.