HGH Fragment 176-191
Synthetic HGH fragment for fat loss
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• Major cities (JHB, CPT, DBN): R195 overnight
• Outlying areas: R275 (2-3 business days)
• Collect in person: Free (Sandton location)
HGH Fragment 176-191 is a synthetic, modified terminal fragment of the human growth hormone polypeptide. This specific sequence is engineered to retain the potent lipolytic properties of HGH while excluding the domains responsible for growth promotion and insulin resistance. It is designed exclusively for targeted metabolic research applications. ##
- •Potent, targeted stimulation of lipolysis.
- •Elimination of undesirable growth promotion effects.
- •Avoidance of insulin resistance induction.
- •High specificity for fat oxidation studies.
- •Approximately 12.5 times greater potency for fat loss than full-length HGH.
- •Ideal for comparative studies on metabolic regulation.
HGH Fragment 176-191 is believed to exert its effects primarily by mimicking the action of the native growth hormone on adipose tissue. At a cellular level, it selectively binds to receptors on adipocytes, stimulating the breakdown of triglycerides into free fatty acids and glycerol, a process known as lipolysis. Unlike the full HGH molecule, this fragment does not appear to activate the IGF-1 cascade, which is responsible for systemic growth and proliferation. The fragment achieves its enhanced lipolytic activity by concentrating the necessary structural information within the C-terminus, specifically residues 176-191. Research suggests it inhibits the formation of new lipids (lipogenesis) in fat cells while simultaneously accelerating the catabolism of existing fat, providing a dual mechanism for targeted fat reduction in research models. ##
This peptide is a critical tool for endocrinology and metabolic syndrome research, particularly in studies focused on obesity and energy expenditure. Its unique profile allows researchers to isolate the effects of lipolysis from the confounding variables of systemic growth and altered glucose homeostasis. Primary applications include investigating the molecular pathways governing fat metabolism, assessing therapeutic potential for obesity management without diabetogenic side effects, and examining the differential receptor binding affinity compared to the full-length growth hormone. Furthermore, it serves as a valuable control agent in studies evaluating novel anti-obesity compounds.
Based on research applications and synergistic mechanisms, this peptide is frequently combined with:
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Angelique
5 February 2026
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Research Use Only
This product is sold strictly for research purposes only. It is not approved by the FDA for human consumption or medical use. Intended for laboratory and research applications by qualified researchers and institutions only.