NAD+
Cellular energy and longevity coenzyme
This product ships with bacteriostatic water included.
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• Major cities (JHB, CPT, DBN): R195 overnight
• Outlying areas: R275 (2-3 business days)
• Collect in person: Free (Sandton location)
Nicotinamide Adenine Dinucleotide ($\text{NAD}^+$) is an essential redox cofactor present in all living cells. It serves as a central metabolite in energy transfer reactions, facilitating the movement of electrons between metabolic pathways. $\text{NAD}^+$ is critical for maintaining cellular homeostasis and viability across diverse biological systems.
- •Supports investigation of mitochondrial function and respiration.
- •Enables study of $\text{NAD}^+$-dependent enzyme kinetics (e.g., sirtuins, PARPs).
- •Essential for analyzing cellular redox state and metabolic flux.
- •Tool for exploring DNA damage response and repair mechanisms.
- •Used in assays targeting aging and longevity pathways.
- •Facilitates research into $\text{NAD}^+$ precursor bioavailability.
$\text{NAD}^+$ functions primarily as an electron acceptor in catabolic processes, transitioning to its reduced form, $\text{NADH}$, which then serves as an electron donor in anabolic processes, notably oxidative phosphorylation. This cycling between $\text{NAD}^+$ and $\text{NADH}$ is fundamental to the regulation of glycolysis, the citric acid cycle, and the electron transport chain, thereby governing cellular energy production (ATP synthesis). Beyond its role in redox reactions, $\text{NAD}^+$ acts as a substrate for various regulatory enzymes. Sirtuins (SIRT) utilize $\text{NAD}^+$ to catalyze deacetylation reactions, linking metabolic status directly to gene expression and protein function. Poly(ADP-ribose) polymerases (PARPs) consume $\text{NAD}^+$ to mediate DNA repair and signaling pathways by transferring ADP-ribose moieties to target proteins.
The study of $\text{NAD}^+$ metabolism is central to understanding age-related decline and chronic diseases. Research utilizes $\text{NAD}^+$ to investigate interventions aimed at boosting cellular $\text{NAD}^+$ levels, such as the use of precursors like Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN), to potentially mitigate metabolic dysfunction and neurodegeneration. Furthermore, $\text{NAD}^+$ is a critical reagent in enzymology and drug discovery. Scientists employ $\text{NAD}^+$ to characterize the activity of $\text{NAD}^+$-consuming enzymes, which are often targets for therapeutic modulation in cancer, inflammation, and cardiovascular disorders. Its application extends to analyzing cellular stress responses and the intricate signaling networks that govern cell survival and programmed cell death.
Reconstitution: Add the volume of bacteriostatic water specified on the product label to achieve the target concentration. Swirl gently until dissolved. NAD+ solutions are light-sensitive — store in amber vials or wrapped in foil.
Research Protocol Overview
| Parameter | Value |
|---|---|
| Typical range | 100–500 mg per administration |
| Frequency | Once daily |
| Timing | Morning |
| Cycle length | 4–12 weeks; or ongoing |
| Route | Subcutaneous injection |
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme central to cellular energy metabolism and a substrate for sirtuins and PARP enzymes. Subcutaneous administration bypasses first-pass metabolism and provides more direct systemic delivery than oral precursors. Research protocols vary widely; 100–500 mg once daily is the most commonly referenced subcutaneous range in the literature. Some protocols employ a loading phase of daily administration for four weeks followed by a reduced maintenance frequency.
Storage: Lyophilised: store at −20 °C; protect from light. Reconstituted: refrigerate at 2–8 °C; use within 2 weeks. Protect from light. Do not freeze reconstituted solution.
For research use only. Not for human consumption.
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29 March 2026
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Research Use Only
This product is sold strictly for research purposes only. It is not approved by the FDA for human consumption or medical use. Intended for laboratory and research applications by qualified researchers and institutions only.