NAD+
Cellular energy and longevity coenzyme
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• Major cities (JHB, CPT, DBN): R195 overnight
• Outlying areas: R275 (2-3 business days)
• Collect in person: Free (Sandton location)
Nicotinamide Adenine Dinucleotide ($\text{NAD}^+$) is an essential redox cofactor present in all living cells. It serves as a central metabolite in energy transfer reactions, facilitating the movement of electrons between metabolic pathways. $\text{NAD}^+$ is critical for maintaining cellular homeostasis and viability across diverse biological systems.
- •Supports investigation of mitochondrial function and respiration.
- •Enables study of $\text{NAD}^+$-dependent enzyme kinetics (e.g., sirtuins, PARPs).
- •Essential for analyzing cellular redox state and metabolic flux.
- •Tool for exploring DNA damage response and repair mechanisms.
- •Used in assays targeting aging and longevity pathways.
- •Facilitates research into $\text{NAD}^+$ precursor bioavailability.
$\text{NAD}^+$ functions primarily as an electron acceptor in catabolic processes, transitioning to its reduced form, $\text{NADH}$, which then serves as an electron donor in anabolic processes, notably oxidative phosphorylation. This cycling between $\text{NAD}^+$ and $\text{NADH}$ is fundamental to the regulation of glycolysis, the citric acid cycle, and the electron transport chain, thereby governing cellular energy production (ATP synthesis). Beyond its role in redox reactions, $\text{NAD}^+$ acts as a substrate for various regulatory enzymes. Sirtuins (SIRT) utilize $\text{NAD}^+$ to catalyze deacetylation reactions, linking metabolic status directly to gene expression and protein function. Poly(ADP-ribose) polymerases (PARPs) consume $\text{NAD}^+$ to mediate DNA repair and signaling pathways by transferring ADP-ribose moieties to target proteins.
The study of $\text{NAD}^+$ metabolism is central to understanding age-related decline and chronic diseases. Research utilizes $\text{NAD}^+$ to investigate interventions aimed at boosting cellular $\text{NAD}^+$ levels, such as the use of precursors like Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN), to potentially mitigate metabolic dysfunction and neurodegeneration. Furthermore, $\text{NAD}^+$ is a critical reagent in enzymology and drug discovery. Scientists employ $\text{NAD}^+$ to characterize the activity of $\text{NAD}^+$-consuming enzymes, which are often targets for therapeutic modulation in cancer, inflammation, and cardiovascular disorders. Its application extends to analyzing cellular stress responses and the intricate signaling networks that govern cell survival and programmed cell death.
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Research Use Only
This product is sold strictly for research purposes only. It is not approved by the FDA for human consumption or medical use. Intended for laboratory and research applications by qualified researchers and institutions only.