Semax
Nootropic peptide for cognitive enhancement
This product ships with bacteriostatic water included.
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Semax is a synthetic heptapeptide analog derived from the corticotropin (ACTH) fragment ACTH(4-10). Originally developed in Russia, this compound exhibits potent nootropic and neuroprotective characteristics. It is classified as a selective cognitive enhancer due to its lack of effect on systemic hormone levels.
- •Enhances cognitive function in research models.
- •Improves memory consolidation and retrieval.
- •Demonstrates robust neuroprotection against ischemic stress.
- •Modulates brain-derived neurotrophic factor (BDNF) expression.
- •Investigated for potential anti-depressant and anxiolytic effects.
- •Supports neuronal survival under conditions of oxidative stress.
Semax functions primarily through interaction with specific brain receptors, notably melanocortin receptors (MCRs), particularly MC4 and MC5. Unlike the full ACTH molecule, Semax lacks peripheral steroidogenic activity. Its neurobiological effects are mediated by modulating the expression and activity of neurotrophins, such as BDNF, which is crucial for synaptic plasticity and neuronal health. Furthermore, Semax influences the metabolism of monoamines, including dopamine and serotonin, within the central nervous system, contributing to its cognitive and mood-regulating properties.
The primary scientific application of Semax lies in the investigation of cognitive enhancement and neuroprotection. It is widely used in preclinical models studying the mechanisms underlying memory formation, learning deficits, and recovery following neurological insults, such as stroke or global ischemia. Researchers utilize Semax to explore novel therapeutic strategies for neurodegenerative conditions and traumatic brain injury, focusing on its ability to stabilize neuronal membranes and mitigate excitotoxicity. Its selective action profile also makes it a valuable tool for studying the specific roles of melanocortin pathways in central nervous system function independent of pituitary-adrenal axis activation.
Semax Dosing Protocol
Vial size: 5 mg lyophilised powder
Reconstitution
Add 3.0 mL of bacteriostatic water to yield a working concentration of approximately 1.67 mg/mL (1,667 mcg/mL). Inject water slowly down the vial wall. Swirl gently until dissolved. Label and refrigerate at 2–8 °C.
At 1.67 mg/mL on a U-100 insulin syringe: 1 unit = 0.01 mL = 16.7 mcg.
Research Protocol Overview
| Parameter | Value |
|---|---|
| Typical range | 200–500 mcg once daily |
| Frequency | Once daily |
| Cycle length | 8–12 weeks continuous; or 6–8 weeks on / 2–4 weeks off |
| Timing | Any consistent time; rotate sites |
| Route | Subcutaneous injection |
Note on half-life: Semax has a short biological half-life. Subcutaneous delivery provides more sustained systemic absorption compared to intranasal administration, making it the preferred route in most research protocols.
Storage
- Lyophilised: Store at −20 °C for long-term.
- Reconstituted: Refrigerate at 2–8 °C; use within 4 weeks. Avoid freeze-thaw cycles.
For research use only. Not for human consumption.
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Research Use Only
This product is sold strictly for research purposes only. It is not approved by the FDA for human consumption or medical use. Intended for laboratory and research applications by qualified researchers and institutions only.