TB-500
PopularThymosin Beta-4 for tissue regeneration and angiogenesis
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• Major cities (JHB, CPT, DBN): R195 overnight
• Outlying areas: R275 (2-3 business days)
• Collect in person: Free (Sandton location)
TB-500 (Thymosin Beta-4) is a synthetic 43-amino acid peptide, naturally occurring in high concentrations within platelets and wound fluid. It is a critical regulator of cellular migration, differentiation, and tissue repair processes. This peptide serves as an essential research tool for investigating wound healing, tissue remodeling, and regenerative medicine mechanisms.
- •Regulates actin polymerization essential for cytoskeletal dynamics and cell motility.
- •Promotes rapid cell migration to injury sites for accelerated tissue repair studies.
- •Supports angiogenesis through enhanced endothelial cell migration and vessel formation.
- •Modulates inflammation by downregulating pro-inflammatory cytokines.
- •Enhances tissue remodeling and minimizes scar tissue formation.
- •Supports stem cell differentiation and tissue-specific cell development research.
- •Demonstrates protective properties in cardiovascular and neurological research models.
TB-500's primary function involves the regulation of actin, a highly abundant eukaryotic protein. The peptide binds to G-actin monomers, promoting actin polymerization and rapid cytoskeletal reorganization necessary for cell motility, division, and structural integrity. By sequestering actin, TB-500 ensures a readily available pool of actin for immediate cellular response during wound healing and migration. The peptide promotes cell migration by modulating the extracellular matrix and upregulating cell adhesion molecules. It enhances endothelial cell migration, supporting the neovascularization (angiogenesis) required for tissue recovery. TB-500 exhibits anti-inflammatory effects by suppressing key pro-inflammatory mediators (e.g., TNF-α, IL-1β) and influencing the activity of matrix metalloproteinases (MMPs) to ensure organized tissue remodeling and prevent excessive fibrosis. Furthermore, TB-500 protects cells from apoptosis under stress conditions and may enhance stem cell differentiation and targeted migration.
TB-500 is extensively utilized in studies focusing on musculoskeletal injury and tissue repair, including investigations into tendon, ligament, and muscle regeneration. Its role in promoting organized tissue remodeling makes it crucial for research on wound healing, fibrosis reduction, and post-surgical recovery protocols. Key scientific applications include cardiovascular research, particularly concerning cardiac remodeling and protection following ischemic injury, and neurological studies investigating neuroprotection, neuronal survival, and axonal regeneration. TB-500 is also fundamental in stem cell biology research, comparative studies with other regenerative peptides (like BPC-157), and applications in tissue engineering to understand and manipulate cellular dynamics and the body’s natural regenerative capacity.
Based on research applications and synergistic mechanisms, this peptide is frequently combined with:
TB-500
This item
R360.00
Reusable Peptide Pen
Premium reusable peptide pen with dial-a-dose mechanism. Compatible with 3ml glass cartridges. Available in 12 colours. Includes carry case.
Out of stock
R340.00
Total for 1 item:
R360.00
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Research Use Only
This product is sold strictly for research purposes only. It is not approved by the FDA for human consumption or medical use. Intended for laboratory and research applications by qualified researchers and institutions only.